SUNY Eye Institute

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Travis Bailey PhD

SUNY Geneseo, Biology

Current Position: Assistant Professor

Keywords Research Areas: Retina; development; degeneration; regeneration; Müller glia; retinal stem cell; retinal progenitor cell

Research Focus:

Fundamental Retinal Processes
Ocular Genetics
Retinal Diseases
Retinal Neuroscience

Clinical Relevance:

Age-Related Macular Degeneration
Diabetic Retinopathy
Glaucoma
Hereditary Eye Diseases
Retinitis Pigmentosa/Retinal Degenerations

Synopsis Of Research:

Zebrafish spontaneously regenerate lost neurons following trauma and are tractable model organisms for the study of the genetics of eye development. Understanding the mechanisms that control both the development and
regeneration of the fish retina should lead to strategies to stimulate regeneration of damaged and degenerated retinal neurons in people.

Current Or Representative Publications:

Gemberling M, Bailey TJ, Hyde DR, Poss KD. The zebrafish as a model for complex tissue regeneration. Trends Genet. 2013 Nov;29(11):611-20.

Bailey TJ, Fossum SL, Fimbel SM, Montgomery JE, Hyde DR. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses muller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91(5):601-12.

Thummel R, Bailey TJ, Hyde DR. In vivo electroporation of morpholinos into the adult zebrafish retina. J Vis Exp. 2011 Dec 27;(58):e3603. doi(58):e3603.

Bailey TJ, Davis DH, Vance JE, Hyde DR. Spectral-domain optical coherence tomography as a noninvasive method to assess damaged and regenerating adult zebrafish retinas. Invest Ophthalmol Vis Sci. 2012 May 31;53(6):3126-38.

Nelson CM, Ackerman KM, O'Hayer P, Bailey TJ, Gorsuch RA, Hyde DR. Tumor necrosis factor-alpha is produced by dying retinal neurons and is required for muller glia proliferation during zebrafish retinal regeneration. J Neurosci. 2013 Apr 10;33(15):6524-39.