Synopsis Of Research:
Dr. Hyman has devoted her career to the study of causes and treatment of leading causes of visual impairment. She is an ocular epidemiologist with expertise in observational epidemiologic studies and clinical trials. She conducted the first large scale case-control study to identify risk factors for the disease and followed up on these findings by conducting another NEI-funded study to separately evaluate factors for neovascular and non-neovascular age related macular degeneration. She is currently the Principal Investigator for the Coordinating Center for two NIH supported multi-center studies- the “Correction of Myopia Evaluation Trial (COMET)/Collaborative Observational Study of Myopia Progression in COMET Children(COSMICC)”, and the Diabetes and Periodontal Therapy Trial (DPTT). COMET began as a multi-center clinical trial that evaluated whether progressive addition lenses (i.e., no-line bifocals) were effective in slowing myopia progression compared to single vision lenses (the conventional treatment) in children with mild to moderate juvenile onset myopia and has continued as an observational study of myopia progression and stabilization which is now in its 12th year of follow-up. She also served as the co-principal Investigator for the Data Center for the Early Manifest Glaucoma Trial (EMGT) and a co-investigator for the Barbados Eye Studies. Dr. Hyman is also the curriculum director of an NIH K30 grant, a training program for clinical researchers that includes a didactic component and development of a research protocol.

Current Or Representative Publications:

 

Hyman L, Schachat AP, He Q, Leske MC.  Hypertension, cardiovascular disease and age-related macular degeneration. Arch Ophthalmol  2000;118:351-358.

Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M and the EMGT Group.  Reduction of Intraocular Pressure and Glaucoma Progression - Results from the Early Manifest Glaucoma Trial.  Arch Ophthalmol 2002;120:1268-1279.  (a) Editorial:  Lichter PR.  Expectations from Clinical Trials:  Results of the Early Manifest Glaucoma Trial.  Arch Ophthalmol 2002;120:1371-2.  (b) Impact of Intraocular Pressure Reduction on Glaucoma Progression.  (Commentary by Paul R. Lichter, MD) JAMA 2002;20:2607-8.) 

Gwiazda J, Hyman L, Hussein M, Everett D, Norton T, Kurtz D, Leske MC, Manny R, Marsh-Tootle W, Scheiman M and the COMET Study Group.  A Randomized Clinical Trial of Progressive Addition Lenses Versus Single Vision Lenses on the Progression of Myopia in Children. Invest Ophthalmol & Vis Sci 2003;44(4):1492-1500.

Hyman L, Gwiazda J, Hussein M, Norton TT, Wang Y, Marsh-Tootle W, Everett D and the COMET Group.  Relationship of Age, Gender and Ethnicity with Myopia Progression and Axial Elongation in the Correction of Myopia Evaluation Trial (COMET).  Arch Ophthalmol 2005; 123(7):977-987.

Hyman L, Heijl A,  Leske MC, Bengtsson B, Yang Z for the EMGTGroup. Natural History of Intraocular Pressure in the Early Manifest Glaucoma Trial (EMGT) - a 6 year follow-up. Arch Ophthalmol. 2010 May;128(5):601-7.