SUNY Eye Institute

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Christopher C. Goulah

SUNY Buffalo, Ophthalmology & Biochemistry

Current Position: Senior Postdoctoral Scientist

Keywords Research Areas: retinal pigment epithelium; oxysterols; oxidative stress; autophagy; proteomics & metabolomics

Research Focus:

Retinal Diseases
Retinal Neuroscience

Clinical Relevance:

Hereditary Eye Diseases
Retinitis Pigmentosa/Retinal Degenerations

Synopsis Of Research:

A pharmacologically-induced rat model of Smith-Lemli-Opitz Syndrome (SLOS) is utilized to study the extended biochemical defects of the disorder at the genomic, proteomic and metabolomic levels with particular focus on retinal degeneration.

Current Or Representative Publications:

Goulah, C.C., Zhu, G., Koszelak-Rosenblum, M., Malkowski, M.G. The crystal structure of α-dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily. Biochemistry [e-published February 1, 2013]
Keller, R.K., Mitchell, D.A., Goulah, C.C., Fliesler, S.J. Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz syndrome. Lipids [e-published January 30, 2013]

Research:

Program of Study: Postdoctoral

Start Date of Program: September 2011

Title of Project: Genomic, Proteomic and Metabolomic analysis of retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome (SLOS)

Mentor: Steven Fliesler, PhD