Christopher C. Goulah
SUNY Buffalo, Ophthalmology & Biochemistry
Current Position: Senior Postdoctoral Scientist
Keywords Research Areas: retinal pigment epithelium; oxysterols; oxidative stress; autophagy; proteomics & metabolomics
Research Focus:
  • Retinal Diseases
  • Retinal Neuroscience
Clinical Relevance:
  • Hereditary Eye Diseases
  • Retinitis Pigmentosa/Retinal Degenerations
Synopsis Of Research:

A pharmacologically-induced rat model of Smith-Lemli-Opitz Syndrome (SLOS) is utilized to study the extended biochemical defects of the disorder at the genomic, proteomic and metabolomic levels with particular focus on retinal degeneration.

Current Or Representative Publications:
  1. Goulah, C.C., Zhu, G., Koszelak-Rosenblum, M., Malkowski, M.G. The crystal structure of α-dioxygenase provides insight into diversity in the cyclooxygenase-peroxidase superfamily. Biochemistry [e-published February 1, 2013]
  2. Keller, R.K., Mitchell, D.A., Goulah, C.C., Fliesler, S.J. Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz syndrome. Lipids [e-published January 30, 2013]
Research:

 

Program of Study: Postdoctoral

Start Date of Program: September 2011

Title of Project: Genomic, Proteomic and Metabolomic analysis of retinal degeneration in a rat model of Smith-Lemli-Opitz Syndrome (SLOS)

Mentor: Steven Fliesler, PhD

State University of New York Medical Centers & College of Optometry Consortium

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